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**Indian Patents Filed**

[2] Vignesh, S.V., Hariprasad, K., Bhartiya, S. “Serial flow continuous separation process for enhancing key component purity”, IPA No. 2602/MUM/2015 (Filed on July 08, 2015)

[1] Hariprasad, K., Bhartiya, S. “Simulated Moving Bed Chromatographic Apparatus”, IPA No. 1947/Mum/2015 (Filed May 18, 2015)

**BOOK CHAPTERS**

[1] K.P. Madhavan, Bhartiya, S., Control of Bioconversion Processes, in Technologies for Converting Biomass to Useful Energy,pp. 453-498 Edited by, Dahlquist, E., Volume 4 of Sustainable Energy Developments, CRC Press Taylor and Francis, 2013

**PUBLICATIONS (PEER REVIEWED)**

[47] Sen Gupta, S. Shastri, S. Bhartiya, “Model-based optimization of biodiesel production from microalgae”, Computers & Chemical Engineering, (Accepted), (2016)

[46] Somvanshi, P.R., A.K. Patel, S. Bhartiya, K.V. Venkatesh, “”Influence of plasma macronutrient levels on hepatic metabolism: role of regulatory networks in homeostasis and disease states”, RSC Advances, 6, 14344-14371, (2016)

[45] Vignesh, S.V., Hariprasad, K., Athawale, P., Siram, V., and S. Bhartiya, “Optimal Strategies for Transitions in Simulated Moving Bed Chromatography”, Computers & Chemical Engineering, 84, 83-95, (2016)

[44] Hariprasad, K., and S. Bhartiya, “A computationally efficient robust tube based MPC for switched systems”, Nonlinear Analysis: Hybrid Systems, 19, 60-76, (2016)

[43] Somvanshi, P.R., Patel, A.K., S. Bhartiya and K.V. Venkatesh, “Implementation of Integral Feedback Control in Biological Systems”, Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 7, 301-316, (2015)

[42] Kottakki, K.K., S. Bhartiya and M. Bhushan, "Optimization based constrained unscented Gaussian sum filter", Computer Aided Chemical Engineering, 37,1715-1720, (2015)

[41] Sen Gupta, S., Bhartiya, S., Shastri,S., “The practical implementation of microalgal biodiesel: challenges and potential solutions”, CAB Reviews, 9(20), 1-12, (2014)

[40] Kottakki, K.K., Bhartiya ,S., Bhushan, M., “State estimation of nonlinear dynamical systems using nonlinear update based Unscented Gaussian Sum Filter”, Journal of Process Control, 24(9), 1425-1443, (2014)

[39] Patel, A.K., Bhartiya, S., Venkatesh, K.V., “Analysis of osmoadaptation system in budding yeast suggests that regulated degradation of glycerol synthesis enzyme is key to near-perfect adaptation”, Systems and Synthetic Biology, 8(2), 141-154, (2014)

[38] Anbumathi, P., Bhartiya, S., Venkatesh, K.V., “Quantitative Analysis of a Dynamic Cell Cycle Regulatory Model of Schizosaccharomyces pombe”, Current Synthetic & Systems Biology, 1(1), doi:10.4172/2332-0737.1000105, (2013)

[37] Hariprasad, K., Bhartiya, S., Gudi, R.D.,A gap metric based multiple model approach for nonlinear switched systems ,Journal of Process Control 22 (9) , pp. 1743-1754, (2012).

[36] Parmar, J.H., Bhartiya, S., Venkatesh, K.V.,Quantification of metabolism in Saccharomyces cerevisiae under hyperosmotic conditions using elementary mode analysis ,Journal of Industrial Microbiology and Biotechnology 39 (6) , pp. 927-941, (2012). [35] V. Pannala, S. Hazarika, S. Bhartiya and K.V. Venkatesh, “A comprehensive growth-related dynamic model of GAL system in Saccharomyces cerevisiae”, IET Systems Biology, 6(2):44-53, (2012). [34] Patil, B.V., Nataraj, P.S.V., and Bhartiya,S., “Global Optimization of Mixed-Integer Nonlinear (Polynomial) Programming Problems: The Bernstein Polynomial Approach,” Computing, 94(2-4), 325-343 (2012) [33] Patil BV, Nataraj PSV, Bhartiya S, Nandola N. Multiple-model based predictive control of nonlinear hybrid systems based on global optimization using the Bernstein polynomial approach, Journal of Process Control. ; 22 (2): 423-435, (2012) [32] Gaikwad, A.J., Vijayan, P.K., Bhartiya, S., Kumar, R., Lele, H.G., Vaze, K.K. , An innovative approach for Steam Generator Pressure Control of a nuclear power plant,Nuclear Engineering and Design 241 (12) , pp. 5113-5126, (2011) [31] Anbumathi, P., Bhartiya, S., Venkatesh, K.V., Mathematical modeling of fission yeast Schizosaccharomyces pombe cell cycle: exploring the role of multiple phosphatases, Systems and Synthetic Biology , pp. 1-15, (2011) [30] A. Gupta, S. Bhartiya, P.S.V. Nataraj, “A novel approach to multiparametric quadratic programming”, Automatica 47, 2112-2117, (2011) [29] V.R. Pannala, K.Y. Ahammed Sherief, S. Bhartiya and K.V. Venkatesh, “Dynamic analysis of the KlGAL regulatory system in Kluyveromyces lactis: a comparative study with Saccharomyces cerevisiae”, Systems and Synthetic Biology, 5, 69-85, (2011) [28] J.H. Parmar, S. Bhartiya and K.V. Venkatesh, “Characterization of the adaptive response and growth upon hyperosmotic shock in Saccharomyces cerevisiae”, Molecular BioSystems, 7, 1138-1148, (2011) [27] Gaikwad, A. J., Vijayan, P. K., Bhartiya, S., Kumar, R., Lele, H. G., & Vaze, K. K. “Selection of steam drum level control method for multiple drum interacting loops pressure tube-type BWR”, IEEE Transactions on Nuclear Science, 58, 479-489, (2011). [26] V.R. Pannala, S. Bhartiya and K.V. Venkatesh, “Experimental and steady-state analysis of the GAL regulon in Kluyveromyces lactis”, FEBS Journal, 277, 2987-3002 (2010) [25] V.R. Pannala, P.J. Bhat, S. Bhartiya and K.V. Venkatesh, “Systems biology of GAL regulon in Saccharomyces cerevisiae”, Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2, 98-106 (2010) [24] Gaikwad, A. J., Vijayan, P. K., Iyer, K., Bhartiya, S., Kumar, R., Lele, H. G., et al. “Effect of loop configuration on steam drum level control for a multiple drum interconnected loops pressure tube type boiling water reactor”, IEEE Transactions on Nuclear Science, 56, 3712-3725, (2009) [23] J.H. Parmar, S. Bhartiya and K.V. Venkatesh, “A model-based study delineating the roles of the two signaling branches in Saccharomyces cerevisiae, Sho1 and Sln1, during adaptation to osmotic stress”, Physical Biology, 6, 036019-036031 (2009) [22] N. Nandola, and S. Bhartiya, “A computationally efficient scheme for model predictive control of nonlinear hybrid systems using generalized outer approximation”, Industrial & Engineering Chemistry Research, 48, 5767-5778 (2009) [21] N. Nandola, and S. Bhartiya, “Hybrid system identification using a structural approach and its model based control: An experimental validation”, Nonlinear Analysis: Hybrid Systems, 3, 87-100 (2009). [20] N.U. Padhiyar and S. Bhartiya, “Profile Control in Distributed Parameter Systems Using Lexicographic Optimization Based MPC”, Journal of Process Control,19, 100-109, (2009) [19] N. Nandola and S. Bhartiya, “A multiple model approach for predictive control of hybrid systems”, Journal of Process Control, 18, 131-148 (2008). [18] N. Chaudhury, S. Bhartiya , and K.V. Venkatesh, “System Analysis of Tryptophan Regulation In Escherichia coli – Performance Under Starved And Well-fed Conditions”, IET Systems Biology, 1 (3), 181-189 (2007). [17] P.M. Bapat, N.U. Padhiyar, N.D. Dave, S. Dash, S. Bhartiya, and P.P. Wangikar, “Model based optimization of multi substrate feeding recipe for Rifamycin B fermentation in complex media”, AIChE Journal, 52, 4248-4257(2006).[16] N. U. Padhiyar, A. Gupta, A. Gautam, S. Bhartiya, F.J. Doyle III, S. Gaikwad and S. Dash, “Nonlinear Inferential Multi-Rate Control Of Kappa Number At Multiple Locations In A Continuous Pulp Digester” Journal of Process Control, 16, 1037-1053 (2006). [15] N. U. Padhiyar, S. Bhartiya, and R.D. Gudi, “Optimal Grade Transition in Polymerization Reactors: A Comparative Case Study”, Industrial & Engineering Chemistry Research, 45, 3583-3592, (2006) [14] S. Chandrasekaran, S. Bhartiya, and P.P. Wangikar, “Substrate specificity of lipases in alkoxycarbonylation reaction: QSAR model development and experimental validation”, Biotechnology and Bioengineering, 94, 554-564, (2006). [13] S. Bhartiya, N. Chaudhary, K.V. Venkatesh, and F.J. Doyle, “Multiple feedback loop design in the tryptophan regulatory network of Escherichia coli suggests a paradigm for robust regulation of processes in series”, Journal of the Royal Society Interface, 3, 383-391, (2006) [12] P.M. Bapat, S. Bhartiya, K.V. Venkatesh, and P.P. Wangikar, “Structured kinetic model to represent the utilization of multiple substrates in complex media during rifamycin B fermentation”, Biotechnology and Bioengineering, 93, 779-790, (2006). [11] P. Dufour, S. Bhartiya, P.S. Dhurjati, and F.J. Doyle, "Neural network based soft sensor: Training set design and application to a continuous pulp digester", Control Engineering Practice, 13, 135-143, (2005). [10] M. Verma, P.J. Bhat, S. Bhartiya, and K.V. Venkatesh, “A steady state modeling approach to validate in vivo mechanism of GAL regulatory mechanism in Saccharomyces cerevisiae”, European Journal of Biochemistry, 271, 4064-4074, (2004). [9] A. Ruhela, M. Verma, J.S. Edwards, P.J. Bhat, S. Bhartiya, K.V. Venkatesh, “Autoregulation of regulatory proteins is key for dynamic operation of GAL switch in Saccharomyces cerevisiae”, FEBS Letters, 576, 119-126, (2004). [8] S. Bhartiya, “Feedstock grade transition in a continuous pulp digester using model based management of kappa profile”, IPPTA: Quarterly Journal of Indian Pulp and Paper Technical Association, 16, 25-28, (2004). [7] S. Bhartiya, and F.J. Doyle, “Mathematical model predictions of a plugging phenomenon in an industrial single vessel pulp digester”, Industrial & Engineering Chemistry Research, 43, 5225-5232, (2004). [6] K.V. Venkatesh, S. Bhartiya, and A. Ruhela, “Multiple feedback loops are key to a robust dynamic performance of tryptophan regulation in Escherichia coli”, FEBS Letters, 563, 234-240, (2004). [5] S. Bhartiya, Subodh Rawool, and K.V. Venkatesh*, "Dynamic Model of Escherichia coli Tryptophan Operon Shows an Optimal Structural Design", European Journal of Biochemistry, 270, 2644-2651, (2003). [4] S. Bhartiya, P. Dufour and F.J. Doyle III, "Fundamental thermal-hydraulic continuous pulp digester model with grade transition", AIChE Journal, 49, 411-425 (2003). [3] S. Bhartiya and J.R. Whiteley, "Benefits of factorized RBF based nonlinear MPC", Computers & Chemical Engineering, 26, 1185-1199 (2002). [2] S. Bhartiya and J.R. Whiteley, "Factorized approach to nonlinear MPC using a radial basis function model", AIChE Journal, 47, 358-368 (2001). [1] S. Bhartiya and J.R. Whiteley, "Development of inferential measurements using neural networks", ISA Transactions, 40, 307-323 (2001).[40] Sharma, G., Vignesh, S.V., Hariprasad, K., Bhartiya, S., “Control-Relevant Multiple Linear Modeling of Simulated Moving Bed Chromatography”, Proceedings of 9th International Symposium on Advanced Control of Chemical Processes (ADCHEM 2015), Whistler, British Columbia, Canada, June 7-10, (2015)

[39] Kottakki, K.K., Bhartiya, S., Bhushan, M., “Optimization based constrained unscented Gaussian sum filter”, 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering, Copenhagen, Denmark, May 31 – June 4, (2015)

[38] Hariprasad, K., Bhartiya, S., “Adaptive robust model predictive control of nonlinear systems using tubes based on interval inclusions”, 53rd IEEE Conference on Decision and Control (CDC 2014), Los Angeles, December 15-17, (2014)

[37] Krishna, K.K, Bhushan, M., Bhartiya, S., “Interval constrained state estimation using unscented Gaussian Sum filter”, Australian Control Conference AUCC 2014, Canberra, November 17-18, (2014)

[36] Gupta, S.S., S. Bhartiya and Y. Shastri, “Model-based optimization of integrated algae biorefinery”, 3rd International Conference on Advances in Control and Optimization of Dynamical Systems (ACODS-2014), Kanpur, March 13-15, (2014)

[35] Adwani, A., R.D. Gudi, and S. Bhartiya, “Control loop performance assessment for two degree of freedom controller: Analysis of model-plant mismatch”, 3rd International Conference on Advances in Control and Optimization of Dynamical Systems (ACODS-2014), Kanpur, March 13-15, (2014)

[34] Hariprasad, K., Bhartiya, S., “A computationally efficient stabilizing model predictive control of switched systems”, 3rd International Conference on Advances in Control and Optimization of Dynamical Systems (ACODS-2014), Kanpur, March 13-15, (2014)

[33] Krishna, K.K, Bhartiya, S., Bhushan, M., “An improved Gaussian Sum Unscented Kalman Filter”, 3rd International Conference on Advances in Control and Optimization of Dynamical Systems (ACODS-2014), Kanpur, 13-15 March, (2014)

[32] Krishna, K.K, Bhushan, M., Bhartiya, S., “Nonlinear Update Based Unscented Gaussian Sum Filter”, IFAC International Symposium on Dynamics and Control of Process Systems (DYCOPS 2013), Mumbai, 18-20 December (2013)

[31] Hariprasad, K., Bhartiya, S., “A dual-terminal set based robust tube MPC for switched systems”, IFAC International Symposium on Dynamics and Control of Process Systems (DYCOPS 2013), Mumbai, 18-20 December (2013)

[30] Airan, A., Bhartiya, S., Bhushan, M., “Linear Machine: A Novel Approach to Point Location Problem”, IFAC International Symposium on Dynamics and Control of Process Systems (DYCOPS 2013), Mumbai, 18-20 December (2013) [29] Athawale, A., Hariprasad, K., Siram V., Bhartiya, S., “Optimal operating strategies for Simulated Moving Bed Chromatography”, IFAC International Symposium on Dynamics and Control of Process Systems (DYCOPS 2013), Mumbai, 18-20 December (2013)[28] Somvanshi, P., Patel, A.K., K. V. Venkatesh, Bhartiya, S. “Analysis of Integrated Insulin-mTOR Signaling Network -Diabetes Perspective”, Computer Applications in Biotechnology (CAB 2013), Mumbai, 18-20 December (2013)

[27] Gupta, A., Bhartiya, S., Nataraj, P.S.V. ,,Explicit-model predictive control: A simulation based scalability study ,2012IFAC Proceedings Volumes (IFAC-PapersOnline) 8 (PART 1) , pp. 204-209[26] Hariprasad, K.H., Bhartiya, S., Gudi, R.D. ,A multiple linear modeling approach for nonlinear switched systems,2012,IFAC Proceedings Volumes (IFAC-PapersOnline) 8 (PART 1) , pp. 63-68

[25] B.V. Patil, S. Bhartiya, and P.S.V. Nataraj, “Application of the Bernstein Form for Reliable Global Optimization of Mixed-Integer Problems in Process Synthesis and Design,” Proceedings of International Conference on Reliability, Safety, and Hazard (ICRESH 2010), Navi Mumbai, India, pp. 562-567, December 14-16, (2010)

[24] B.V. Patil, P.S.V. Nataraj, and S. Bhartiya, “Global Optimization of Mixed-Integer Nonlinear (Polynomial) Programming Problems: The Bernstein Polynomial Approach,” Proceedings of International Symposium on Scientific Computing, Computer Arithmetic and Validated Numerics (SCAN 2010), ENS de Lyon, France, pp. 116-117, September 27-30, (2010)

[23] B. Thapliyal, R.M. Mathur, A. Gupta, M. Gupta and S.Bhartiya, “Modelling of Wheat Straw pulping in a Pandia Digester and Inferential Estimation of Kappa Number using Irregulatory sampled and delayed Measurement”, Control Systems 2010, Stockholm, Sweden, September 15-17, (2010)

[22] V. Prasad, V.R. Pannala, S. Bhartiya, and K.V. Venkatesh, “Comparative stochastic analysis of the GAL switch in Saccharomyces cerevisiae and Kluyveromyces lactis: modeling and experiments”, Systems Biology session, AIChE Annual Meeting Conference, Nashville Tennessee, November 8-13, (2009)

[21] P. Anbumathi, S. Bhartiya, and K.V. Venkatesh, “Mathematical Modelling of Cell Signaling Networks: Cell Cycle Regulation of Schizosaccharomyces pombe” Poster 3.013, The 10th International Conference on systems biology ICSB 2009, Stanford, California, August 30- September 04, (2009)

[20] V.R. Pannala, S. Bhartiya, and K.V. Venkatesh, “A Model Driven Comparative Study of the GAL System in Saccharomyces cerevisiae and Kluyveromyces lactis”, Proceedings of the Foundations of Systems Biology in Engineering (FOSBE) 2007, pp. 205-208, Denver, Colorado, USA, August 9-12, (2009)

[19] J.H. Parmar, S. Bhartiya, and K.V. Venkatesh, “Charactization of the Adaptive Response Upon Hyperosmotic Shock in Saccharomyces cerevisiae” Proceedings of the Foundations of Systems Biology in Engineering (FOSBE) 2007, pp. 209-213, Denver, Colorado, USA, August 9-12, (2009)

[18] B. Thapliyal, R.M. Mathur, M. Gupta, S. Singh, A. Dixit, and S. Bhartiya, “Modeling and Online Inferential Estimation of Kappa Number for Wheat Straw Pulping in a Pandia Digester”, PaperTech India 2008, Mumbai, India, Sept 18-21, (2008).

[17] N.U. Padhiyar and S. Bhartiya, “Optimal Grade Transition in a Continuous Pulp Digester”, Control Systems/Pan Pacific (PAPTAC) 2008, Vancouver, Canada, June 16-18, (2008).

[16] N.N. Nandola and S. Bhartiya, “Predictive Control of Nonlinear Hybrid Systems Using Generalized Outer Approximation”, Proceedings of the IFAC World Congress, pp 3624-3628, Seoul, Korea, July 6-11, (2008).[15] N.N. Nandola and S. Bhartiya, “Modeling of interaction of Programmable Logic Controllers and Model Predictive Control as Hybrid System”, International Conference on Engineering Technologies and Application in Engineering, Technology and Science,Vol. 1, pp 781-786, Rajkot, India , January 13-14 (2008).

[14] Venkat Reddy Pannala, Saumar Jyoti Hazarika, P.J. Bhat, Sharad Bhartiya and K.V. Venkatesh. “A Modified Model of the GAL System in Saccharomyces cerevisiae Shows Robust Behavior in Presence of Autoregulation”, Proceedings of the Foundations of Systems Biology in Engineering (FOSBE) 2007, pp. 71-76, September 9-12, 2007, Stuttgart, Germany, (2007).

[13] Padhiyar, N., Bhartiya, 2007, “A Novel MPC Formulation For Profile Control In a Distributed Parameter System” , Proceedings of Dynamics and Control of Process Systems (DYCOPS 2007), Preprint Vol. 1, pp. 111-116, Cancún , Mexico June 6-8, (2007).

[12] Padhiyar, N., Bhartiya, 2006, “Profile Control Using Lexicographic Method For a Distributed Parameter System”, CHEMCON 2006, Ankleshwar, December 27-30, (2006).

[11] N. Padhiyar, S. Bhartiya, and R.D. Gudi, “Optimal Grade Transition in Polymerization Reactors: A Comparative Case Study”, ADCHEM 2006 Preprints, Vol 1, pp. 265-270, Gramado, Brazil, April 2-5, (2006).

[10] N.N. Nandola, and S. Bhartiya, “Control of Nonlinear Hybrid Systems Using Multiple MLD Models”, Session #553, AIChE Annual Meeting Conference Proceedings, pp. 7283-7284, Cincinnati, Ohio, November (2005)

[9] V. Bavdekar, K.V. Venkatesh, and S. Bhartiya, “Ultrasensitivity in Genetic Networks Is a Key Requirement for Noise Mitigation”, Session #379, AIChE Annual Meeting Conference Proceedings, pp. 6771-6773, Cincinnati, Ohio, November (2005)

[8] S. Bhartiya, S. BenAmor, P. Dhurjati, F.J. Doyle, S. Dash, and S. Gaikwad, "Process Modeling, Control, and Monitoring for a Continuous Kamyr Digester", Proceedings of International Symposium on Process Systems Engineering and Control, pp. 145-150, Mumbai, India, January 3-4 (2003)

[7] S. Bhartiya, and F.J. Doyle, "Modeling and control of grade transition in a dual vessel continuous pulp digester", Control Systems 2002 Conference Proceedings, pp. 239-243, Stockholm, Sweden, June 3-5 (2002)

[6] S. Bhartiya, F.J. Doyle, F. Kayihan, S. Dash, S. Gaikwad, S. Sharp, P. Hart, J. Ou, “Online implementation of a fundamental model for a continuous Kamyr Digester”, Advanced Process Control Applications for Industry Workshop, (preprint available), Vancouver, Canada, April 29-May 01, (2002)

[5] S. Bhartiya, P. Dufour, and F.J. Doyle, "Thermal-hydraulic modeling of a continuous pulp digester", Digester Workshop, Annapolis, MD, (preprint available), June 28, (2001)

[4] P. Dufour, S. Bhartiya, A. Bills, P.S. Dhurjati, and F.J. Doyle, "A neural network approach for the diagnosis of the continuous pulp digester", Digester Workshop, Annapolis, MD, (preprint available), June 28, (2001)

[3] P. Dufour, S. Bhartiya, T.J. English, E.P. Gatzke, P.S. Dhurjati, and F.J. Doyle, "Fault detection in the continuous pulp digester", Pre-prints of IFAC Workshop on Online Fault Detection and Supervision in the Chemical Process Industries (CHEMFAS - 4), pp. 106-111, Seoul, South Korea, June 7-8, (2001)

[2] S.K. Haware, S. Bhartiya, A.K. Ghosh, and V.V. Raj, "Analytical Studies on the Behaviour of Nuclear Reactor Containments", Paper No. HMT95-097, Proceedings of ISHMT-ASME, 2nd International Conference on Heat and Mass Transfer, Surathkal, India, December 28-30, (1993)

[1] S.K. Haware, S. Bhartiya, A.K. Ghosh, and V.V. Raj, "Studies on Catalytic Recombination of Hydrogen in Pressurized Heavy Water Reactor", Paper No. HMT95-096, Proceedings of ISHMT-ASME, 2nd International Conference on Heat and Mass Transfer, Surathkal, India, December 28-30, (1993)