Drug Delivery

Liposomal Drug Delivery System

Stationary Phase Interdiffusion is a new technique to make liposomes of uniform diameter. Currently adopted methods for encapsulating drugs using this method is very inefficient (less than 5%), whereas it can theoretically be as high as 80%). This study will focus on improving the encapsulation efficiency by first understanding the reasons of poor efficiency, and adopting techniques used elsewhere to increase the efficiency of encapsulation. The study will be potentially be carried out in collaboration with a pharma industry, with a possibility of carrying out an internship there.

Proposing Faculty
Research Area
  • Colloids
  • Drug Delivery
  • Nanoparticles
  • Product Development
  • Surfactants

Microfluidics based approach to drug encapsulation into microcapsules

Microfluidics provides a robust platform for cell
encapsulation and drug delivery due to the precise control it provides. In this
project microfluidic devices will be designed to encapsulate drugs into  read more »

Proposing Faculty
Research Area
  • Biomaterials
  • Drug Delivery
  • Microscopy

Aerosol synthesis of insulin containing nanoparticles for inhalation delivery

co-guide: Y.S. Mayya  read more »

Proposing Faculty
Research Area
  • Biomaterials
  • Drug Delivery
  • Nano-composites
  • Nanoparticles
Venkat Gundabala

A Method and an Apparatus for Synthesizing Vesicles by Interdiffusion of Stationary Phases

The present invention relates to a method and an apparatus for synthesizing stable uni-lamellar vesicles (liposomes) for drug delivery and similar applications. The main advantage over existing methods is the ability to produce in a single step, stable liposomes of a mono-disperse population in the size range of 200-5000nm controlled by temperature and lipid type alone, without subjecting to harsh environments and with negligible external energy supplied. The method of the present invention is simple, feasible and inexpensive for the large-scale production of liposomes.

Mini Extruder(Avanti Polar Lipids Inc. )

thin film extruder.jpg

The Avanti Mini-Extruder allows the preparation of small unilamellar vesicles from different lipid species by extrusion. The heating block allows the extrusion of unilamellar vesicles at elevated temperatures, which is critical for the successful production of vesicles from phospholipids with a phase transition temperature (Tm) above room temperature.

Web links:
http://www.avantilipids.com/index.php?option=com_content&view=article&id...
http://www.avantilipids.com/index.php?option=com_content&view=article&id...

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Molecular Modelling Software

Materials Studio is a comprehensive materials modeling and simulation application designed for scientists in chemicals and materials R&D as well as pharmaceuticals development. Materials Studio reduces the time needed to solve complex calculations with:
• Industry-leading graphical user environments
• State-of-the-art simulation technology from quantum to atomistic to mesoscale
• Powerful statistical tools for structure-property relationships  read more »

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High Speed Camera

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Model V12.1, PHANTOM, Vision Research, AMETEK

Captures images @ 6242 frames per second at full 1280 x 800 widescreen resolution and 1,000,000 pictures-per-second at reduced resolution. The camera supports 8- and 12-bit pixel depth. Equipped with Phantom Software and a Cinemag interface.

Additional accessories include image-based auto-trigger, an internal mechanical shutter for remote/automatic CSRs, Canon EOS lens mount.

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Microforge-Grinding Center

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Model details: MFG-5 Microforge-Grinding Center, MDI Micro Data instruments , Inc., USA
Description:  read more »

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Micromanipulator

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Model details: Three-axis water hydraulic micromanipulator, MHW-3, Narishige Co.Ltd. Japan
Description:
This instrument facilitates precise maneuvering of samples under microscope.

Applications:

For patch clamping experiments to study of single or multiple ion channels in cells.
Attachments available:
B-9 Ball joint. This highly stable ball joint was developed for patch clamping. Allows free rotation and approach from many different angles.  read more »

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