Drug Delivery

Venkat Gundabala

A Method and an Apparatus for Synthesizing Vesicles by Interdiffusion of Stationary Phases

The present invention relates to a method and an apparatus for synthesizing stable uni-lamellar vesicles (liposomes) for drug delivery and similar applications. The main advantage over existing methods is the ability to produce in a single step, stable liposomes of a mono-disperse population in the size range of 200-5000nm controlled by temperature and lipid type alone, without subjecting to harsh environments and with negligible external energy supplied. The method of the present invention is simple, feasible and inexpensive for the large-scale production of liposomes.

Mini Extruder(Avanti Polar Lipids Inc. )

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The Avanti Mini-Extruder allows the preparation of small unilamellar vesicles from different lipid species by extrusion. The heating block allows the extrusion of unilamellar vesicles at elevated temperatures, which is critical for the successful production of vesicles from phospholipids with a phase transition temperature (Tm) above room temperature.

Web links:
http://www.avantilipids.com/index.php?option=com_content&view=article&id...
http://www.avantilipids.com/index.php?option=com_content&view=article&id...

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Molecular Modelling Software

Materials Studio is a comprehensive materials modeling and simulation application designed for scientists in chemicals and materials R&D as well as pharmaceuticals development. Materials Studio reduces the time needed to solve complex calculations with:
• Industry-leading graphical user environments
• State-of-the-art simulation technology from quantum to atomistic to mesoscale
• Powerful statistical tools for structure-property relationships  read more »

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High Speed Camera

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Model V12.1, PHANTOM, Vision Research, AMETEK

Captures images @ 6242 frames per second at full 1280 x 800 widescreen resolution and 1,000,000 pictures-per-second at reduced resolution. The camera supports 8- and 12-bit pixel depth. Equipped with Phantom Software and a Cinemag interface.

Additional accessories include image-based auto-trigger, an internal mechanical shutter for remote/automatic CSRs, Canon EOS lens mount.

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Microforge-Grinding Center

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Model details: MFG-5 Microforge-Grinding Center, MDI Micro Data instruments , Inc., USA
Description:  read more »

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Micromanipulator

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Model details: Three-axis water hydraulic micromanipulator, MHW-3, Narishige Co.Ltd. Japan
Description:
This instrument facilitates precise maneuvering of samples under microscope.

Applications:

For patch clamping experiments to study of single or multiple ion channels in cells.
Attachments available:
B-9 Ball joint. This highly stable ball joint was developed for patch clamping. Allows free rotation and approach from many different angles.  read more »

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CCD Camera

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Description:
CCD camera converts optical brightness into electrical amplitude signals using charge coupled device (CCD) image sensor. The CCD image sensor includes an image sensing section, which performs photoelectric conversion, and a storage section, which is arranged separate from the image sensing section and temporarily stores charges acquired by the photoelectric conversion. The charge collected and stored in an array of semiconductors represents a picture element or pixel of an image.
Components:
1) IEEE 1394 FireWire Digital interface  read more »

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Inverted Microscope, TE 2000 – U, Nikon

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Model details:
Model TE 2000 – U, Nikon-Inverted microscope
Description:
Microscope with its light source and condenser on the top, above the stage pointing down, while the objectives and turret are below the stage pointing up. The stage on an inverted microscope is usually fixed, and focus is adjusted by moving the objective lens along a vertical axis to bring it closer to or further from the specimen. The focus mechanism typically has a dual concentric knob for coarse and fine adjustment.
Useful for:  read more »

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Bench-top pH meter

benchtop pH meter

Model-Control Dynamic pH meter
Student In charge-Renu Kulkarni
-A pH meter is an electronic instrument used to measure the pH (acidity or alkalinity) of a liquid (though special probes are sometimes used to measure the pH of semi-solid substances). A typical pH meter consists of a special measuring probe (a glass electrode) connected to an electronic meter that measures and displays the pH reading.  read more »

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