The present invention relates to a method and an apparatus for synthesizing stable uni-lamellar vesicles (liposomes) for drug delivery and similar applications. The main advantage over existing methods is the ability to produce in a single step, stable liposomes of a mono-disperse population in the size range of 200-5000nm controlled by temperature and lipid type alone, without subjecting to harsh environments and with negligible external energy supplied. The method of the present invention is simple, feasible and inexpensive for the large-scale production of liposomes.

Contact angle meter.jpg

Model DS  read more »

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Model AFCBP1  read more »

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Freeze dry_Labconco.jpg

Freeze drying or lyophilization is the process of drying a material that has been frozen, without going through the liquid phase. The FreeZone 2.5 Liter Benchtop Freeze Dry Systems have dual refrigeration systems for small load of samples with very low eutectic points. The dehydration technique enables liquid or slurry products which have previously been frozen to be dried under a vacuum.
Web Links:
http://www.labconco.com/_scripts/editc25.asp?catid=347
http://www.directindustry.com/prod/labconco/laboratory-freeze-dryer-3070...

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Cryo TEM instrument.JPG

Model Tecnai G2 12 BioTWIN  read more »

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nanosurf_AFM.jpg

The AFM consists of a cantilever with a sharp tip at its end. Multiple white LEDs illuminate the sample for proper positioning and setup. The tip is brought into close proximity of a sample surface. The force between the tip and the sample leads to a deflection of the cantilever according to Hooke's law. Typically, the deflection is measured using a laser spot reflected from the top of the cantilever. The tip is then scanned across the sample surface and the vertical displacement s necessary to maintain a constant force on the tip is recorded.  read more »

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Nikon inverted microscope.jpg

This microscope has its light source and condenser on the top, above the stage pointing down, while the objectives and turret are below the stage pointing up. The stage on an inverted microscope is usually fixed, and focus is adjusted by moving the objective lens along a vertical axis to bring it closer to or further from the specimen. The focus mechanism typically has a dual concentric knob for coarse and fine adjustment.  read more »

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thin film extruder.jpg

The Avanti Mini-Extruder allows the preparation of small unilamellar vesicles from different lipid species by extrusion. The heating block allows the extrusion of unilamellar vesicles at elevated temperatures, which is critical for the successful production of vesicles from phospholipids with a phase transition temperature (Tm) above room temperature.

Web links:
http://www.avantilipids.com/index.php?option=com_content&view=article&id...
http://www.avantilipids.com/index.php?option=com_content&view=article&id...

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Model details: Model No. MDF-U41865, Ultra low, Sanyo

Features:
• Ultra-low temperature freezer maintains internal temperatures as low as -80⁰C freezing environment by means of conventional insulation walls.
• Microprocessor temperature control with digital input for precise setting and control.
• Built-in temperature and power failure alarms (audible/visible).

Applications:
Storage of biological samples like RNA, cDNA and protein samples.

Reference: http://www.sanyobiomedical.com/products_page.php?id=MDF-U5386

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Materials Studio is a comprehensive materials modeling and simulation application designed for scientists in chemicals and materials R&D as well as pharmaceuticals development. Materials Studio reduces the time needed to solve complex calculations with:
• Industry-leading graphical user environments
• State-of-the-art simulation technology from quantum to atomistic to mesoscale
• Powerful statistical tools for structure-property relationships  read more »

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