Microfluidic cell plate is a platform technology that combines micro and macro fluidic components, lab-on-a-chip devices, microscopy methods, analytical methods and imaging technologies. It allows to work interactively with all the components in a customized approach. The core component of this system is the micro flow through cell, which is typically made up of polydimethylsiloxane (PDMS) and glass. The continuous passage of fluids to the cell is completely controlled by an extrenal syrnige pumps. It additionally consists of a casting station with the accessories of casting tool, silicon master chips, polycarbonate lid, and PDMS monomer to fabricate and recycle the PDMS-CPs (Polydimethylsiloxane channel plates). This system is widely used for live microbial cell imaging and single molecule detection.