Systems and synthetic biology are two important emerging, inter-disciplinary, inter-related fields. Systems biology approaches use the principles of biology, physical sciences, engineering and mathematics to systematically understand and quantitate the functioning of biological systems. Biology being astoundingly complex, several novel systems biology based experimental, theoretical and computational approaches have been developed in the last decade to decipher various principles that govern the functioning of cells and their response. Synthetic biology approaches involve design and construction of new biological functions, and modification of existing biological function. Synthetic biology utilizes artificial networks to introduce specific phenotypic characteristics into a cell. The short introductory course aims to present various complexities involved in biological systems, the systematic approaches that can help understand the associated challenges, and methods to tweak their functioning for useful purposes.